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KMID : 1140120090140010007
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Cancer Prevention Research
2009 Volume.14 No. 1 p.7 ~ p.15
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Meta-analysis of Asian Epidemiological Studies on the Association between Obesity and Esophageal Cancer
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Sung Nak-Jin
Oh Sang-Woo
Kang Min-Soo
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Abstract
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There were several studies on the association between obesity and esophageal cancer in Asian countries which showed variable outcomes. We did a meta-analysis to estimate summary effects on that association. Eight sets of data were extracted from 6 papers which were selected through Pubmed searches during 1985∼2007 and hand searches of bibliographies in these studies. Meta-analysis of 4 data sets on esophageal squamous cell carcinoma incidence showed summary relative risk 0.66 (95% CI: 0.51∼0.86) per 5 kg/m2 higher BMI. Meta-analysis of 3 data sets on histologically unverified esophageal cancer revealed summary relative risk 0.62 (95% CI: 0.54∼0.72) per 5 kg/m2 higher BMI. In conclusion, obesity in Asians was associated with decreased incidence of esophageal squamous cell carcinoma. Obesity was also associated with decreased incidence of all esophageal cancer, which was thought to be mainly due to predominant prevalence of esophageal squamous cell carcinoma over adenocarcinoma in Asian countries.
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KEYWORD
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Obesity, Esophagus, Cancer, Meta-analysis, Asia
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